First-Ever GC Xenograft Created in CBTP Lab

Perhaps the greatest milestone in 2016 came when Dr. Uday Bhanu Maachani established two gliomatosis cerebri cell cultures from living patients. From one of these lines he created a xenograft: A mouse model with a GC tumor sampled from an actual patient. This is the only animal model anywhere in the world with a GC tumor cultured from a patient.

In August, Dr. Maachani injected mice with tumor cells from a patient with GC; imaging a month later confirmed that he had created the first animal model of an actual patient tumor. At top are bioluminescence images and at bottom is an axial MRI scan that clearly shows the GC tumor as the bright white spot in the striatum (cortex) of the brain.
In August, Dr. Maachani injected mice with tumor cells from a patient with GC; imaging a month later confirmed that he had created the first animal model of an actual patient tumor. At top are bioluminescence images and at bottom is an axial MRI scan that clearly shows the GC tumor as the bright white spot in the striatum (cortex) of the brain.

Why is this so exciting? The promise at the heart of precision medicine is one-to-one matching of disease and cure—creating a xenograft from a patient tissue sample allows us to test promising treatments against that individual’s exact tumor in a living model. We are tremendously excited by this advance, even as we face our next hurdle: identifying and gaining access to a drug with the best chance of destroying that tumor.