Project Description

ALL ACADEMIC PUBLICATIONS

Peer-reviewed publications validate research findings because they subject the authors scholarly work to a high level of scrutiny from other experts in the field who evaluate whether an article is suitable for publication. The volume of published work from the team at the Children’s Brain Tumor Project is a testament to the hard work and dedication of our lab team. Below is a just a selection of articles that our team has contributed to in recent years.

SCIENTIFIC REPORTS – October 2020

Robust deep learning classification of adamantinomatous craniopharyngioma from limited preoperative radiographic images

Eric W Prince 1 2 3Ros Whelan 4David M Mirsky 5Nicholas Stence 5Susan Staulcup 4Paul Klimo 6 7Richard C E Anderson 8Toba N Niazi 9Gerald Grant 10Mark Souweidane 11 12James M Johnston 13Eric M Jackson 14David D Limbrick Jr 15Amy Smith 16Annie Drapeau 17Joshua J Chern 18Lindsay Kilburn 19Kevin Ginn 20Robert Naftel 21Roy Dudley 22Elizabeth Tyler-Kabara 23George Jallo 24Michael H Handler 25 4Kenneth Jones 26Andrew M Donson 27 28Nicholas K Foreman 27 28Todd C Hankinson 25 4 27

JOURNAL OF NEUROSURGERY PEDIATRICS – SEPTEMBER 2020

Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma.

Bander ED, Ramos AD, Wembacher-Schroeder E, Ivasyk I, Thomson R, Morgenstern PF, Souweidane MM.
PMID: 32977309

SCIENTIFIC ADVANCES – JULY 2020

PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models.

Tosi U, Kommidi H, Adeuyan O, Guo H, Maachani UB, Chen N, Su T, Zhang G, Pisapia DJ, Dahmane N, Ting R, Souweidane MM
PMID: 32832670

PHARMACEUTICS – JULY 2020

Convection Enhanced Delivery for Diffuse Intrinsic Pontine Glioma: Review of a Single Institution Experience

by Umberto Tosi and Mark Souweidane

ACTA NEUROPATHOLOGICA COMMUNICATIONS – JUNE 2020

Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.

Pisapia DJ, Ohara K, Bareja R, Wilkes DC, Hissong E, Croyle JA, Kim JH, Saab J, MacDonald TY, Beg S, O’Reilly C, Kudman S, Rubin MA, Elemento O, Sboner A, Greenfield J, Mosquera JM.
PMID: 32493417

NEURO-ONCOLOGY ADVANCES – MAY 2020

Missing diversity in brain tumor trials.

Taha B, Winston G, Tosi U, Hartley B, Hoffman CDahmane N, Mason CE, Greenfield JP.

PMID: 32642711

ACTA NEUROPATHOLOGICA COMMUNICATIONS – May 2020

Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets

Eric Prince, Ros WhelanAndrew DonsonSusan StaulcupAstrid HengartnerTrinka VijmasiChibueze AgwuKevin O LilleheiNicholas K Foreman, James M JohnstonLuca MassimiRichard C E AndersonMark M SouweidaneRobert P NaftelDavid D LimbrickGerald GrantToba N NiaziRoy DudleyLindsay KilburnEric M JacksonGeorge I JalloKevin GinnAmy SmithJoshua J ChernAmy LeeAnnie DrapeauMark D KriegerMichael H HandlerTodd C HankinsonAdvancing Treatment for Pediatric Craniopharyngioma Consortium

PMID: 32404202 PMCID: PMC7222517

NEURO-ONCOLOGY – APRIL 2020 

A Combined Approach of Convection-Enhanced Delivery of Peptide Nanofiber Reservoir to Prolong Delivery of DM1 for Diffuse Intrinsic Pontine Glioma Treatment.

Bellat V, Alcaina Y, Tung CH, Ting R, Michel A, Souweidane M, Law B.

PMID: 32301996

TRANSLATIONAL ONCOLOGY – FEB 2020

B7-H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric Central Nervous System Tumors.

Maachani UB, Tosi U, Pisapia DJ, Mukherjee S, Marnell CS, Voronina J, Martinez D, Santi M, Dahmane N, Zhou Z, Hawkins C, Souweidane MM. Download free PMC article here.

WORLD NEUROSURGERY – FEB 2020

Longitudinal Monitoring of Gd-DTPA Following Convection Enhanced Delivery in the Brainstem.

Tosi U, Souweidane MM.

PMID:32028001

NEUROSURGICAL FOCUS – JANUARY 2020

Deformational Changes After Convection-Enhanced Delivery in the Pediatric Brainstem
(Pediatric Brain Tumor: Evolving Treatment Strategies)

Bander ED, Tizi K, Wembacher-Schroeder E, Thomson R, Donzelli M, Vasconcellos E, Souweidane MM.

JOURNAL OF NEUROSURGERY PEDIATRICS – DECEMBER 2019

The Intersect of Neurosurgery with Diffuse Intrinsic Pontine Glioma 

Kuzan-Fischer CM, Souweidane MM

FRONTIERS IN COMPUTATIONAL NEUROSCIENCE – DECEMBER 2019

Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients.

Rathore S, Akbari H, Bakas S, Pisapia JM, Shukla G, Rudie JD, Da X, Davuluri RV, Dahmane N, O’Rourke DM, Davatzikos C.

PMID:31920606

NEURO-ONCOLOGY ADVANCES – MAY-DECEMBER 2019

Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy

Raymond Chang, Umberto Tosi, Julia Voronina, Oluwaseyi Adeuyan, Linda Y Wu, Melanie E Schweitzer, David J Pisapia, Oren J Becher, Mark M Souweidane, Uday B Maachani

JOURNAL OF CLINICAL ONCOLOGY – DECEMBER 2019

Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A COG Study

Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G.

PMID: 31786541

ACTA NEUROPATHOLOGIA COMMUNICATIONS – NOVEMBER 2019

Immune landscapes associated with different glioblastoma molecular subtypes.

Martinez-Lage M, Lynch TM, Bi Y, Cocito C, Way GP, Pal S, Haller J, Yan RE, Ziober A, Nguyen A, Kandpal M, O’Rourke DM, Greenfield JP, Greene CS, Davuluri RV, Dahmane N.2019 Nov 29;7(1):203. doi: 10.1186/s40478-019-0803-6.

PMID: 31815646

JOURNAL OF CLINICAL ONCOLOGY – NOVEMBER 2019

Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A COG Study

Lafay-Cousin L, Bouffet E, Strother D, Rudneva V, Hawkins C, Eberhart C, Horbinski C, Heier L, Souweidane M, Williams-Hughes C, OnarThomas A, Billups CA, Fouladi M, Northcott P, Robinson G, Gajjar A.

PMID: 31774708

JCO PRECISION ONCOLOGY – SEPTEMBER 2019

Integrative Molecular Analysis of Patients With Metastatic Cancer

Sailer V, Eng KW, Zhang T, Bareja R, Pisapia DJ, Sigaras A, Bhinder B, Romanel A, Wilkes D, Sticca E, Cyrta J, Rao R, Sahota S, Pauli C, Beg S, Motanagh S, Kossai M, Fontunge J, Puca L, Rennert H, Zhaoying Xiang J, Greco N, Kim R, MacDonald TY, McNary T, Blattner-Johnson M, Schiffman MH, Faltas BM, Greenfield JP, Rickman D, Andreopoulou E, Holcomb K, Vahdat LT, Scherr DS, van Besien K, Barbieri CE, Robinson BD, Fine HA, Ocean AJ, Molina A, Shah MA, Nanus DM, Pan Q, Demichelis F, Tagawa ST, Song W, Mosquera JM, Sboner A, Rubin MA, Elemento O, Beltran H.

PMID: 31592503

ONCOLOGY TIMES – NOVEMBER 2019

2019 Excellence in Oncology Award—Dr. Mark Souweidane Honorable Mention. Direct Delivery to Brainstem in Rare Pediatric Tumor Proves Safe.

AUTHOR: Chuck Holt

JOURNAL OF NEUROSURGERY PEDIATRICS – SEPTEMBER 2019

Developing a 3D composite training model for cranial remodeling.

Cheng D, Yuan M, Perera I, O’Connor A, Evins AI, Imahiyerobo T, Souweidane M, Hoffman C.

MOLECULAR PHARMACOLOGY – AUGUST 2019

An [18F]-Positron Emitting Fluorophore Allows Safe Evaluation of Small Molecule Distribution in CSF, CSF Fistulas, and CNS Device Placement.

Guo H, Kommidi H, Maachani UB, Voronina JC, Zhang W, Magge RS, Ivanidze J, Wu AP, Souweidane MM, Aras O, Ting R.

PMID: 31290330

ACTA NEUROCHIRURGICA (WIEN) – AUGUST 2019

Endonasal surgery for suprasellar germ cell tumors: two cases and review of the literature.

Arnaout MM, Gerges MM, Cummock MD, El Asri AC, Greenfield JP, Anand VK, Schwartz TH.

OXFORD ACADEMIC NEURO-ONCOLOGY ADVANCES – MAY 2019

Combined Targeting of PI3K and MEK Effector Pathways via CED for DIPG Therapy

Raymond Chang, Umberto Tosi, Julia Voronina, Oluwaseyi Adeuyan, Y Linda Wu, Melanie E Schweitzer, David J Pisapia, Oren J Becher, Mark M Souweidane, Uday B Maachani.  Read more about the paper here.

ACS CHEMICAL NEUROSCIENCE – MAY 2019

Real-Time, in Vivo Correlation of Molecular Structure with Drug Distribution in the Brain Striatum Following Convection Enhanced Delivery.

Tosi U, Kommidi H, Bellat V, Marnell CS, Guo H, Adeuyan O, Schweitzer ME, Chen N, Su T, Zhang G, Maachani UB, Pisapia DJ, Law B, Souweidane MM, Ting R.ACS Chem Neurosci. 2019 May 15;10(5):2287-2298. doi: 10.1021/acschemneuro.8b00607. Epub 2019 Mar 6.
PMID:30838861

ACTA NEUROPATHOLOGICAL COMMUNICATIONS – APRIL 2019

Transcriptome signatures associated with meningioma progression.

Viaene AN, Zhang B, Martinez-Lage M, Xiang C, Tosi U, Thawani JP, Gungor B, Zhu Y, Roccograndi L, Zhang L, Bailey RL, Storm PB, O’Rourke DM, Resnick AC, Grady MS, Dahmane N.

PMID:31039818

NATURE – JANUARY 2019

Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.

Miller AM, Shah RH, Pentsova EI, Pourmaleki M, Briggs S, Distefano N, Zheng Y, Skakodub A, Mehta SA, Campos C, Hsieh WY, Selcuklu SD, Ling L, Meng F, Jing X, Samoila A, Bale TA, Tsui DWY, Grommes C, Viale A, Souweidane MM, Tabar V, Brennan CW, Reiner AS, Rosenblum M, Panageas KS, DeAngelis LM, Young RJ, Berger MF, Mellinghoff IK.
Nature. 2019 Jan;565(7741):654-658. doi: 10.1038/s41586-019-0882-3. Epub 2019 Jan 23.
PMID: 30675060

NATURE – JANUARY 2019

18F-Radiolabeled Panobinostat Allows for Positron Emission Tomography Guided Delivery of a Histone Deacetylase Inhibitor.

Kommidi H, Tosi U, Maachani UB, Guo H, Marnell CS, Law B, Souweidane MM, Ting R.ACS Med Chem Lett. 2018 Jan 17;9(2):114-119. doi: 10.1021/acsmedchemlett.7b00471. eCollection 2018 Feb 8.

Nature. 2019 Jan;565(7741):654-658. doi: 10.1038/s41586-019-0882-3. Epub 2019 Jan 23.

PMID:30675060 FREE DOWNLOAD

JOURNAL OF NEUROSURGERY – DECEMBER 2018

Clinical tolerance of corticospinal tracts in convection-enhanced delivery to the brainstem.

Morgenstern PF, Zhou Z, Wembacher-Schröder E, Cina V, Tsiouris AJ, Souweidane MM

PMID: 30579270 DOI: 10.3171/2018.6.JNS18854

LANCET ONCOLOGY – AUGUST 2018

Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial.

Souweidane MM, Kramer K, Pandit-Taskar N, Zhou Z, Haque S, Zanzonico P, Carrasquillo JA, Lyashchenko SK, Thakur SB, Donzelli M, Turner RS, Lewis JS, Cheung NV, Larson SM, Dunkel IJ.Lancet Oncol. 2018 Aug;19(8):1040-1050. doi: 10.1016/S1470-2045(18)30322-X. Epub 2018 Jun 18. Erratum in: Lancet Oncol. 2018 Aug;19(8):e382.
PMID: 29914796
MOLECULAR THERAPY ONCOLYTICS – AUGUST 2018

Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas.

Yin Y, Boesteanu AC, Binder ZA, Xu C, Reid RA, Rodriguez JL, Cook DR, Thokala R, Blouch K, McGettigan-Croce B, Zhang L, Konradt C, Cogdill AP, Panjwani MK, Jiang S, Migliorini D, Dahmane N, Posey AD Jr, June CH, Mason NJ, Lin Z, O’Rourke DM, Johnson LA.

PMID:30306125

NEURO-ONCOLOGY – JULY 2018

In vivo evaluation of EGFRvIII mutation in primary glioblastoma patients via complex multiparametric MRI signature.

Akbari H, Bakas S, Pisapia JM, Nasrallah MP, Rozycki M, Martinez-Lage M, Morrissette JJD, Dahmane N, O’Rourke DM, Davatzikos C.

PMID: 29617843

JOURNAL OF NEUROSURGERY – JULY 2018

Volume of distribution and clearance of peptide-based nanofiber after convection-enhanced delivery.

Singh R, Bellat V, Wang M, Schweitzer ME, Wu YL, Tung CH, Souweidane MM, Law B.J Neurosurg. 2018 Jul;129(1):10-18. doi: 10.3171/2017.2.JNS162273. Epub 2017 Sep 8.
PMID:28885119

NEUROONCOLOGY – JUNE 2018

TBIO-06. B7-H3 expression as a potential biomarker of prognosis and target in pediatric glial and non-glial CNS tumors.

Uday Bhanu Maachani, Zhiping Zhou, Daniel Martinez, Mariarita Santi, Nadia Dahmane, and Mark Souweidane.

PMCID: PMC6012773

COLD SPRING HARBOR MOLECULAR CASE STUDIES – APRIL 2018

Precision oncogenomics in pediatrics: a personal reflection.

Campbell C, Greenfield JP.Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002865. doi: 10.1101/mcs.a002865. Print 2018 Apr. Review.
PMID: 29610396. Free PMC Article

JOURNAL OF NUCLEAR MEDICINE – MARCH 2018

PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma.

Jannetti SA, Carlucci G, Carney B, Kossatz S, Shenker L, Carter LM, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gönen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T.

JOURNAL OF NEUROONCOLOGY – MARCH 2018

Patterns of relapse for children with localized intracranial ependymoma.

De B, Khakoo Y, Souweidane MM, Dunkel IJ, Patel SH, Gilheeney SW, De Braganca KC, Karajannis MA, Wolden SL.

PEDIATRIC BLOOD CANCER – JANUARY 2018

A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma.

Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV.Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26754. Epub 2017 Sep 22.
PMID:28940863

PEDIATRIC BLOOD CANCER – SEPTEMBER 2017

A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma.

Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV.Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26754. Epub 2017 Sep 22.
PMID: 28940863

PALLIATIVE SUPPORT CARE – SEPTEMBER 2017

Rapid autopsy of a patient with recurrent anaplastic ependymoma.

Lange KR, Fischer C, Rajappa P, Connors S, Pisapia D, Greenfield JP, Beltran H, Rubin M, Mosquera JM, Khakoo Y. Palliat Support Care. 2018 Apr;16(2):238-242. doi: 10.1017/S1478951517000864. Epub 2017 Sep 25.
PMID:  28942746 Free PMC Article

JCO PRECISION ONCOLOGY – JUNE 2017

Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models.

Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM, Rajappa P, Souweidane MM, Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM.JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00038. Epub 2017 Jun 14.
PMID: 29333526 . Free PMC Article

CLINICAL CANCER RESEARCH – JUNE 2017

Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells.

Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP.

PMID:28039266
JOURNAL OF CLINICAL INVESTIGATION – MAY 2017

A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma.

Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J.

PMID:28394259

CANCER RESEARCH – APRIL 2017

Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.

Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T.

PMID:28108511
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