CHILD’S NERVOUS SYSTEM – OCTOBER 2025
Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population.
Giantini-Larsen AM, Garton ALA, Rivera M, Han R, Pisapia DJ, Sait SF, Karajannis MA, Greenfield JP, Bilsky MH, Newman WC, Souweidane MM.Childs Nerv Syst. 2025 Oct 7;41(1):306. doi: 10.1007/s00381-025-06903-4.PMID: 41055765
NEUROONCOLOGY PEDIATRICS – AUGUST 2025
MODL-10. Two novel patient-derived xenograft models for pediatric pineal tumors allow for the detection of cell therapy candidates.
Carolina Cocito, Christopher Padilla, Alexandra Backlund, David Pisapia, Benjamin Liechty, Mark Souweidane, Nadia Dahmane, Jeffrey Greenfield Neuro-Oncology Pediatrics, Volume 1, Issue Supplement_1, ABSTRACTS FROM 2025 SNO PEDIATRIC NEURO-ONCOLOGY CONFERENCE
SCIENTIFIC REPORTS – JULY 2025
Single-dose radiotherapy is more effective than fractionation when combined with anti-PD-1 immunotherapy in glioblastoma.
Cocito C, Branchtein M, Zhou XK, Gongora T, Dahmane N, Greenfield JP.Sci Rep. 2025 Jul 2;15(1):22910. doi: 10.1038/s41598-025-06909-7.PMID: 40596223
FRONTIERS IN IMMUNOLOGY – JULY 2025
Checkpoint antibody receptor modified ARMed CAR T circumvents the suppressive immunome in GBM.
Cook DR, Boesteanu AC, Yin Y, Reid R, Roccograndi L, Dahmane N, Martinez-Lage M, O’Rourke DM, June CH, Johnson LA.Front Immunol. 2025 Jul 31;16:1579925. doi: 10.3389/fimmu.2025.1579925. eCollection 2025.PMID: 40821779
NEURO-ONCOLOGY ADVANCES – JULY 2025
Patterns of relapse in diffuse intrinsic pontine glioma after convection-enhanced delivery of 124I-omburtamab.
Bander ED, Garton ALA, Pasquini L, Reiner AS, Yildirim O, Ilica AT, Donzelli M, Haque S, Souweidane MM.Neurooncol Adv. 2025 Jul 19;7(1):vdaf128. doi: 10.1093/noajnl/vdaf128. eCollection 2025 Jan-Dec.PMID: 40709014
NEUROONCOLOGY – MAY 2025
Designing a time-dependent therapeutic strategy using CDK4/6 inhibitors in an intracranial ATRT model.
Martin B, Guadix SW, Sathian R, Laramee M, Pandey A, Ray I, Wang A, Davuluri R, Thomas CJ, Dahmane N, Souweidane M.Neuro Oncol. 2025 May 15;27(4):1076-1091. doi: 10.1093/neuonc/noae262.PMID: 39657117
JOURNAL OF NEUROONCOLOGY – MAY 2025
Financial toxicity in pediatric and adolescent neurosurgical oncology.
Giantini-Larsen AM, Brown S, Reiner AS, Giandalone SD, Zappi K, Abou-Mrad Z, Khakoo Y, Dunkel IJ, Karajannis MA, Sait SF, Hoffman CE, Greenfield JP, Souweidane MM, Newman WC.J Neurooncol. 2025 May 12. doi: 10.1007/s11060-025-05056-3. Online ahead of print.PMID: 40355786
NEUROONCOLOGY – MAY 2025
Phase 2 trial of veliparib, local irradiation, and temozolomide in patients with newly diagnosed high-grade glioma: a Children’s Oncology Group study.
Karajannis MA, Onar-Thomas A, Lin T, Baxter PA, Boué DR, Cole BL, Fuller C, Haque S, Jabado N, Lucas JT Jr, MacDonald SM, Matsushima C, Patel N, Pierson CR, Souweidane MM, Thomas DL, Walsh MF, Zaky W, Leary SES, Gajjar A, Fouladi M, Cohen KJ.Neuro Oncol. 2025 May 15;27(4):1092-1101. doi: 10.1093/neuonc/noae247.PMID: 39560182 Clinical Trial.
BIORxIV – APRIL 2025
Machine learning-predicted chromatin organization landscape across pediatric tumors.
Gjoni K, Zhang S, Yan RE, Zhang B, Miller D, Resnick A, Dahmane N, Pollard KS.bioRxiv [Preprint]. 2025 Apr 2:2025.03.28.645984. doi: 10.1101/2025.03.28.645984.PMID: 40236019
COMMUNICATIONS MEDICINE – MARCH 2025
The radiogenomic and spatiogenomic landscapes of glioblastoma and their relationship to oncogenic drivers.
Fathi Kazerooni A, Akbari H, Hu X, Bommineni V, Grigoriadis D, Toorens E, Sako C, Mamourian E, Ballinger D, Sussman R, Singh A, Verginadis II, Dahmane N, Koumenis C, Binder ZA, Bagley SJ, Mohan S, Hatzigeorgiou A, O’Rourke DM, Ganguly T, De S, Bakas S, Nasrallah MP, Davatzikos C.Commun Med (Lond). 2025 Mar 1;5(1):55. doi: 10.1038/s43856-025-00767-0.PMID: 40025245
NEUROONCOLOGY – FEBRUARY 2025
Phase 1 dose-escalation trial using convection-enhanced delivery (CED) of radio-immunotheranostic 124I-Omburtamab for diffuse intrinsic pontine glioma (DIPG).
Souweidane MM, Bander ED, Zanzonico P, Reiner AS, Manino N, Haque S, Carrasquillo JA, Lyashchenko SK, Thakur SB, Lewis JS, Donzelli M, Cheung NV, Larson SM, Kramer K, Pandit-Taskar N, Dunkel IJ.Neuro Oncol. 2025 Feb 19:noaf039. doi: 10.1093/neuonc/noaf039. Online ahead of print.PMID: 39969230
SCIENTIFIC REPORTS – FEBRUARY 2025
NEUROONCOLOGY ADVANCES – JANUARY 2025
Therapeutic manipulation and bypass of the blood-brain barrier: powerful tools in glioma treatment.
Giantini-Larsen AM, Pandey A, Garton ALA, Rampichini M, Winston G, Goldberg JL, Magge R, Stieg PE, Souweidane MM, Ramakrishna R.Neurooncol Adv. 2025 Jan 15;7(1):vdae201. doi: 10.1093/noajnl/vdae201. eCollection 2025 Jan-Dec.PMID: 39877748
NATURE BIOTECHNOLOGY – NOVEMBER 2024
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling.
Yan RE, Corman A, Katgara L, Wang X, Xue X, Gajic ZZ, Sam R, Farid M, Friedman SM, Choo J, Raimondi I, Ganesan S, Katsevich E, Greenfield JP, Dahmane N, Sanjana NE. Nat Biotechnol. 2024 Nov 21. doi: 10.1038/s41587-024-02475-x. Epub ahead of print. PMID: 39572737.
WORLD NEUROSURGERY – OCTOBER 2024
Challenges and Outlooks in Precision Medicine: Expectations Versus Reality.
Yan RE, Greenfield JP. World Neurosurg. 2024 Oct;190:573-581. doi: 10.1016/j.wneu.2024.06.142. PMID: 39425299.
WORLD NEUROSURGERY – OCTOBER 2024
Yan RE, Greenfield JP. Emergence of Precision Medicine Within Neurological Surgery: Promise and Opportunity. World Neurosurg. 2024 Oct;190:564-572. doi: 10.1016/j.wneu.2024.06.143. PMID: 39425298.
WORLD NEUROSURGERY – OCTOBER 2024
Uribe-Cardenas R & Greenfield JP. Reimagining the N-Of-1 Trial Within Pediatric Neuro-Oncology: A Shifting Paradigm. World Neurosurgery. 190, 582-585 (2024). https://doi.org/10.1016/j.wneu.2024.06.146
JOURNAL OF CLINICAL MEDICINE – OCTOBER 2024
Yan RE, Chae JK, Dahmane N, Ciaramitaro P, Greenfield JP. The Genetics of Chiari 1 Malformation. J Clin Med. 2024 Oct 16;13(20):6157.
doi: 10.3390/jcm13206157. PMID: 39458107; PMCID: PMC11508843.
JOURNAL OF NUCLEAR MEDICINE – SEPTEMBER 2024
Theranostic Intratumoral Convection-Enhanced Delivery of 124I-Omburtamab in Patients with Diffuse Intrinsic Pontine Glioma
Pandit-Taskar N, Zanzonico PB, Grkovski M, Donzelli M, Vietri SM, Horan C, Serencsits B, Prasad K, Lyashchenko S, Kramer K, Dunkel IJ, Souweidane MM. Pharmacokinetics and Lesion Dosimetry. J Nucl Med. 2024 Sep 3;65(9):1364-1370. doi: 10.2967/jnumed.123.266365. PMID: 39142829; PMCID: PMC11372263.
PEDIATRIC BLOOD AND CANCER – MAY 2024
Hypofractionated re-irradiation for diffuse intrinsic pontine glioma.
Mankuzhy NP, Tringale KR, Dunkel IJ, Farouk Sait S, Souweidane MM, Khakoo Y, Karajannis MA, Wolden S.Pediatr Blood Cancer. 2024 May;71(5):e30929. doi: 10.1002/pbc.30929. Epub 2024 Mar 2.PMID: 38430472
JOURNAL OF NEUROSURGERY CASE LESSONS – FEBRUARY 2024
Laser interstitial thermal therapy as a radiation-sparing approach for central nervous system tumors in children with cancer predisposition syndromes: report of a child with Li-Fraumeni syndrome. Illustrative case
Guadix SW, Pandey A, Gundlach C, Walsh M, Moss NS, Souweidane MM. J Neurosurg Case Lessons. 2024 Feb 5;7(6):CASE23595. doi: 10.3171/CASE23595. PMID: 38315990; PMCID: PMC10849145.
COLD SPRING HARBOR MOLECULAR CASE STUDIES – JANUARY 2024
The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer.
Al Assaad M, Gundem G, Liechty B, Sboner A, Medina J, Papaemmanuil E, Sternberg CN, Marks A, Souweidane MM, Greenfield JP, Tran I, Snuderl M, Elemento O, Imielinski M, Pisapia DJ, Mosquera JM. Cold Spring Harb Mol Case Stud. 2024 Jan 10;9(4):a006275.doi: 10.1101/mcs.a006275. PMID: 37652664; PMCID: PMC10815291.
CANCER CELL – JANUARY 2024
A road map for the treatment of pediatric diffuse midline glioma.
Koschmann C, Al-Holou WN, Alonso MM, Anastas J, Bandopadhayay P, Barron T, Becher O, Cartaxo R, Castro MG, Chung C, Clausen M, Dang D, Doherty R, Duchatel R, Dun M, Filbin M, Franson A, Galban S, Garcia Moure M, Garton H, Gowda P, Marques JG, Hawkins C, Heath A, Hulleman E, Ji S, Jones C, Kilburn L, Kline C, Koldobskiy MA, Lim D, Lowenstein PR, Lu QR, Lum J, Mack S, Magge S, Marini B, Martin D, Marupudi N, Messinger D, Mody R, Morgan M, Mota M, Muraszko K, Mueller S, Natarajan SK, Nazarian J, Niculcea M, Nuechterlein N, Okada H, Opipari V, Pai MP, Pal S, Peterson E, Phoenix T, Prensner JR, Pun M, Raju GP, Reitman ZJ, Resnick A, Rogawski D, Saratsis A, Sbergio SG, Souweidane M, Stafford JM, Tzaridis T, Venkataraman S, Vittorio O, Wadden J, Wahl D, Wechsler-Reya RJ, Yadav VN, Zhang X, Zhang Q, Venneti S.Cancer Cell. 2024 Jan 8;42(1):1-5. doi: 10.1016/j.ccell.2023.11.002. Epub 2023 Nov 30.PMID: 38039965
PEDIATRIC NEUROLOGY – NOVEMBER 2023
Pediatric Postmortem Tissue Donation in the Confines of a Pandemic: A Model of Collaboration
Esteban U. Arias-Stella, Cindy Campbell, David J. Pisapia MD, Carolina Cocito PhD, Sheila McThenia MD, Melanie Degliuomini MD, Jeffrey P. Greenfield MD, PhD, Yasmin Khakoo MD
JOURNAL OF CONTROLLED RELEASE – OCTOBER 2023
NEOPLASIA – MAY 2023
Leptomeningeal dissemination in pediatric brain tumors.
Cocito C, Martin B, Giantini-Larsen AM, Valcarce-Aspegren M, Souweidane MM, Szalontay L, Dahmane N, Greenfield JP.Neoplasia. 2023 May;39:100898. doi: 10.1016/j.neo.2023.100898. Epub 2023 Apr 1.PMID: 37011459
NEUROONCOLOGY – MARCH 2023
Glioma epileptiform activity and progression are driven by IGSF3-mediated potassium dysregulation.
Curry RN, Aiba I, Meyer J, Lozzi B, Ko Y, McDonald MF, Rosenbaum A, Cervantes A, Huang-Hobbs E, Cocito C, Greenfield JP, Jalali A, Gavvala J, Mohila C, Serin Harmanci A, Noebels J, Rao G, Deneen B.Neuron. 2023 Mar 1;111(5):682-695.e9. doi: 10.1016/j.neuron.2023.01.013. Epub 2023 Feb 13.PMID: 36787748
JOURNAL OF HEMATOLOGY AND ONCOLOGY – NOVEMBER 2022
Phase 1 study of intraventricular 131I-omburtamab targeting B7H3 (CD276)-expressing CNS malignancies
Kim Kramer, Neeta Pandit-Taskar, Brian H Kushner, Pat Zanzonico, John L Humm, Ursula Tomlinson, Maria Donzelli, Suzanne L Wolden, Sophia Haque, Ira Dunkel, Mark M Souweidane, Jeffrey P Greenfield, Satish Tickoo, Jason S Lewis, Serge K Lyashchenko, Jorge A Carrasquillo, Bae Chu, Christopher Horan, Steven M Larson, Nai-Kong V Cheung, Shakeel Modak
PMID: 36371226 PMCID: PMC9655863
PEDIATRIC BLOOD AND CANCER – NOVEMBER 2022
Clinical outcomes of pediatric patients receiving multimodality treatment of second central nervous system relapse of neuroblastoma.
Tringale KR, Wolden SL, Casey DL, Kushner BH, Luo L, Pandit-Taskar N, Souweidane M, Cheung NV, Modak S, Basu EM, Kramer K. PMID: 36349892
NEOPLASIA – NOVEMBER 2022
The children’s brain tumor network (CBTN) – Accelerating research in pediatric central nervous system tumors through collaboration and open science.
Lilly JV, Rokita JL, Mason JL, Patton T, Stefankiewiz S, Higgins D, Trooskin G, Larouci CA, Arya K, Appert E, Heath AP, Zhu Y, Brown MA, Zhang B, Farrow BK, Robins S, Morgan AM, Nguyen TQ, Frenkel E, Lehmann K, Drake E, Sullivan C, Plisiewicz A, Coleman N, Patterson L, Koptyra M, Helili Z, Van Kuren N, Young N, Kim MC, Friedman C, Lubneuski A, Blackden C, Williams M, Baubet V, Tauhid L, Galanaugh J, Boucher K, Ijaz H, Cole KA, Choudhari N, Santi M, Moulder RW, Waller J, Rife W, Diskin SJ, Mateos M, Parsons DW, Pollack IF, Goldman S, Leary S, Caporalini C, Buccoliero AM, Scagnet M, Haussler D, Hanson D, Firestein R, Cain J, Phillips JJ, Gupta N, Mueller S, Grant G, Monje-Deisseroth M, Partap S, Greenfield JP, Hashizume R, Smith A, Zhu S, Johnston JM, Fangusaro JR, Miller M, Wood MD, Gardner S, Carter CL, Prolo LM, Pisapia J, Pehlivan K, Franson A, Niazi T, Rubin J, Abdelbaki M, Ziegler DS, Lindsay HB, Stucklin AG, Gerber N, Vaske OM, Quinsey C, Rood BR, Nazarian J, Raabe E, Jackson EM, Stapleton S, Lober RM, Kram DE, Koschmann C, Storm PB, Lulla RR, Prados M, Resnick AC, Waanders AJ.
PMID: 36335802
NEUROONCOLOGY – OCTOBER 2022
Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult brain tumor patients.
Miller AM, Szalontay L, Bouvier N, Hill K, Ahmad H, Rafailov J, Lee AJ, Rodriguez-Sanchez MI, Yildirim O, Patel A, Bale TA, Benhamida JK, Benayed R, Arcila ME, Donzelli M, Dunkel IJ, Gilheeney SW, Khakoo Y, Kramer K, Sait SF, Greenfield JP, Souweidane MM, Haque S, Mauguen A, Berger MF, Mellinghoff IK, Karajannis MA.
PMID: 35148412
PEDIATRIC BLOOD CANCER – SEPTEMBER 2022
A systematic literature review to identify ethical, legal, and social responsibilities of nonprofit organizations when funding clinical trials in pediatric cancer
Vasiliki Rahimzadeh, Susan Wolfert, Vickie Buenger, Cindy Campbell, Robin French, Donna Ludwinski, Amy Weinstein, Caitlyn Barrett
EPIGENOMICS – JUNE 2022
Developments in high throughput functional epigenomics: CRISPR-single-cell assay for transposase-accessible chromatin using sequencing screens
Rachel E Yan, Jeffrey P Greenfield, Nadia Dahmane PMID: 35574596
NEUROONCOLOGY – JUNE 2022
Phase II trial of response-based radiation therapy for patients with localized germinoma: a Children’s Oncology Group study.
Bartels U, Onar-Thomas A, Patel SK, Shaw D, Fangusaro J, Dhall G, Souweidane M, Bhatia A, Embry L, Trask CL, Murphy ES, MacDonald S, Wu S, Boyett JM, Leary S, Fouladi M, Gajjar A, Khatua S.
PMID: 34850169
JOURNAL OF NEUROONCOLOGY – MAY 2022
Quantifying intraventricular drug delivery utilizing programmable ventriculoperitoneal shunts as the intraventricular access device.
McThenia SS, Pandit-Taskar N, Grkovski M, Donzelli MA, Diagana S, Greenfield JP, Souweidane MM, Kramer K.J
PMID: 35403968
LANCET ONCOLOGY – MAY 2022
Imaging response assessment for CNS germ cell tumours: consensus recommendations from the European Society for Paediatric Oncology Brain Tumour Group and North American Children’s Oncology Group.
Morana G, Shaw D, MacDonald SM, Alapetite C, Ajithkumar T, Bhatia A, Brisse H, Jaimes C, Czech T, Dhall G, Fangusaro J, Faure-Conter C, Fouladi M, Hargrave D, Harreld JH, Mitra D, Nicholson JC, Souweidane M, Timmermann B, Calaminus G, Bartels U, Bison B, Murray MJ.
PMID: 35489353
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY AND BIOLOGICAL PHYSICS – MAY 2022
A Phase 2 Trial of Response-Based Radiation Therapy for Localized Central Nervous System Germ Cell Tumors: Patterns of Failure and Radiation Dosimetry for Nongerminomatous Germ Cell Tumors.
Murphy ES, Dhall G, Fangusaro J, Bartels U, Fouladi M, Shaw D, Khatua S, Hughes CW, Panigraphy A, Ioakeim-Ioannidou M, Souweidane M, Morris D, Gajjar A, Wu S, Onar-Thomas A, Haas-Kogan DA, MacDonald SM.
PMID: 34990779
NEUROONCOLOGY ADVANCES – MARCH 2022
Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors.
Rajappa P, Eng KW, Bareja R, Bander ED, Yuan M, Dua A, Bhanu Maachani U, Snuderl M, Pan H, Zhang T, Tosi U, Ivasyk I, Souweidane MM, Elemento O, Sboner A, Greenfield JP, Pisapia DJ.
PMID: 35475276 Free PMC article.
NEUROONCOLOGY – NOVEMBER 2021
Intracranial germ cell tumors in Adolescents and Young Adults: European and North American consensus review, current management and future development
D Frappaz, G Dhall, M J Murray, S Goldman, C Faure Conter, J Allen, R Kortmann, D Haas-Kogen, G Morana, J Finlay, J C Nicholson, Ute Bartels, M Souweidane, S Schöenberger, A Vasiljevic, P Robertson, A Albanese, C Alapetite, T Czech, C C Lau, P Wen, D Schiff, D Shaw, G Calaminus, E Bouffet
JOURNAL OF NEUROSURGERY PEDIATRICS – AUGUST 2021
Intraarterial delivery of bevacizumab and cetuximab utilizing blood-brain barrier disruption in children with high-grade glioma and diffuse intrinsic pontine glioma: results of a phase I trial
Heather J McCrea, Jana Ivanidze, Ashley O’Connor, Eliza H Hersh, John A Boockvar, Y Pierre Gobin, Jared Knopman, Jeffrey P Greenfield
MOLECULAR CELL BIOLOGY – JUNE 2021
RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons
Chaomei Xiang 1, Karla K Frietze 1, Yingtao Bi 2, Yanwen Li 1, Valentina Dal Pozzo, Sharmistha Pal, Noah Alexander, Valerie Baubet, Victoria D’Acunto, Christopher E Mason, Ramana V Davuluri, Nadia Dahmane
JOURNAL OF NEUROSURGERY PEDIATRICS – MAY 2021
Evaluation of a patient-specific algorithm for predicting distribution for convection-enhanced drug delivery into the brainstem of patients with diffuse intrinsic pontine glioma.
Wembacher-Schroeder E, Kerstein N, Bander ED, Pandit-Taskar N, Thomson R, Souweidane MM
SCIENTIFIC REPORTS – OCTOBER 2020
Robust deep learning classification of adamantinomatous craniopharyngioma from limited preoperative radiographic images
Eric W Prince, Ros Whelan, David M Mirsky, Nicholas Stence, Susan Staulcup, Paul Klimo, Richard C E Anderson, Toba N Niazi, Gerald Grant, Mark Souweidane, James M Johnston , Eric M Jackson , David D Limbrick Jr, Amy Smith, Annie Drapeau, Joshua J Chern, Lindsay Kilburn, Kevin Ginn, Robert Naftel, Roy Dudley, Elizabeth Tyler-Kabara, George Jallo, Michael H Handler, Kenneth Jones, Andrew M Donson, Nicholas K Foreman, Todd C Hankinson
JOURNAL OF NEUROSURGERY PEDIATRICS – SEPTEMBER 2020
Repeat convection-enhanced delivery for diffuse intrinsic pontine glioma.
Bander ED, Ramos AD, Wembacher-Schroeder E, Ivasyk I, Thomson R, Morgenstern PF, Souweidane MM. PMID: 32977309
SCIENTIFIC ADVANCES – JULY 2020
PET, image-guided HDAC inhibition of pediatric diffuse midline glioma improves survival in murine models.
Tosi U, Kommidi H, Adeuyan O, Guo H, Maachani UB, Chen N, Su T, Zhang G, Pisapia DJ, Dahmane N, Ting R, Souweidane MM PMID: 32832670
PHARMACEUTICS – JULY 2020
Convection Enhanced Delivery for Diffuse Intrinsic Pontine Glioma: Review of a Single Institution Experience
by Umberto Tosi and Mark Souweidane
ACTA NEUROPATHOLOGICA COMMUNICATIONS – JUNE 2020
Fusions involving BCOR and CREBBP are rare events in infiltrating glioma.
Pisapia DJ, Ohara K, Bareja R, Wilkes DC, Hissong E, Croyle JA, Kim JH, Saab J, MacDonald TY, Beg S, O’Reilly C, Kudman S, Rubin MA, Elemento O, Sboner A, Greenfield J, Mosquera JM.
PMID: 32493417
NEURO-ONCOLOGY ADVANCES – MAY 2020
Missing diversity in brain tumor trials.
Taha B, Winston G, Tosi U, Hartley B, Hoffman C, Dahmane N, Mason CE, Greenfield JP. PMID: 32642711
ACTA NEUROPATHOLOGICA COMMUNICATIONS – May 2020
Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets
Eric Prince, Ros Whelan, Andrew Donson, Susan Staulcup, Astrid Hengartner, Trinka Vijmasi, Chibueze Agwu, Kevin O Lillehei, Nicholas K Foreman, James M Johnston, Luca Massimi, Richard C E Anderson, Mark M Souweidane, Robert P Naftel, David D Limbrick, Gerald Grant, Toba N Niazi, Roy Dudley, Lindsay Kilburn, Eric M Jackson, George I Jallo, Kevin Ginn, Amy Smith, Joshua J Chern, Amy Lee, Annie Drapeau, Mark D Krieger, Michael H Handler, Todd C Hankinson, Advancing Treatment for Pediatric Craniopharyngioma Consortium PMID: 32404202 PMCID: PMC7222517
NEURO-ONCOLOGY – APRIL 2020
A Combined Approach of Convection-Enhanced Delivery of Peptide Nanofiber Reservoir to Prolong Delivery of DM1 for Diffuse Intrinsic Pontine Glioma Treatment.
Bellat V, Alcaina Y, Tung CH, Ting R, Michel A, Souweidane M, Law B. PMID: 32301996
TRANSLATIONAL ONCOLOGY – FEB 2020
B7-H3 as a Prognostic Biomarker and Therapeutic Target in Pediatric Central Nervous System Tumors.
Maachani UB, Tosi U, Pisapia DJ, Mukherjee S, Marnell CS, Voronina J, Martinez D, Santi M, Dahmane N, Zhou Z, Hawkins C, Souweidane MM. Download free PMC article here.
WORLD NEUROSURGERY – FEB 2020
Longitudinal Monitoring of Gd-DTPA Following Convection Enhanced Delivery in the Brainstem.
Tosi U, Souweidane MM. PMID:32028001
NEUROSURGICAL FOCUS – JANUARY 2020
Deformational Changes After Convection-Enhanced Delivery in the Pediatric Brainstem
(Pediatric Brain Tumor: Evolving Treatment Strategies)
Bander ED, Tizi K, Wembacher-Schroeder E, Thomson R, Donzelli M, Vasconcellos E, Souweidane MM.
JOURNAL OF NEUROSURGERY PEDIATRICS – DECEMBER 2019
The Intersect of Neurosurgery with Diffuse Intrinsic Pontine Glioma
Kuzan-Fischer CM, Souweidane MM
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE – DECEMBER 2019
Multivariate Analysis of Preoperative Magnetic Resonance Imaging Reveals Transcriptomic Classification of de novo Glioblastoma Patients.
Rathore S, Akbari H, Bakas S, Pisapia JM, Shukla G, Rudie JD, Da X, Davuluri RV, Dahmane N, O’Rourke DM, Davatzikos C. PMID:31920606
NEURO-ONCOLOGY ADVANCES – MAY-DECEMBER 2019
Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy
Raymond Chang, Umberto Tosi, Julia Voronina, Oluwaseyi Adeuyan, Linda Y Wu, Melanie E Schweitzer, David J Pisapia, Oren J Becher, Mark M Souweidane, Uday B Maachani
JOURNAL OF CLINICAL ONCOLOGY – DECEMBER 2019
Phase II Trial of Response-Based Radiation Therapy for Patients With Localized CNS Nongerminomatous Germ Cell Tumors: A COG Study
Fangusaro J, Wu S, MacDonald S, Murphy E, Shaw D, Bartels U, Khatua S, Souweidane M, Lu HM, Morris D, Panigrahy A, Onar-Thomas A, Fouladi M, Gajjar A, Dhall G. PMID: 31786541
ACTA NEUROPATHOLOGIA COMMUNICATIONS – NOVEMBER 2019
Immune landscapes associated with different glioblastoma molecular subtypes.
Martinez-Lage M, Lynch TM, Bi Y, Cocito C, Way GP, Pal S, Haller J, Yan RE, Ziober A, Nguyen A, Kandpal M, O’Rourke DM, Greenfield JP, Greene CS, Davuluri RV, Dahmane N.2019 Nov 29;7(1):203. doi: 10.1186/s40478-019-0803-6. PMID: 31815646
JOURNAL OF CLINICAL ONCOLOGY – NOVEMBER 2019
Phase II Study of Nonmetastatic Desmoplastic Medulloblastoma in Children Younger Than 4 Years of Age: A COG Study
Lafay-Cousin L, Bouffet E, Strother D, Rudneva V, Hawkins C, Eberhart C, Horbinski C, Heier L, Souweidane M, Williams-Hughes C, OnarThomas A, Billups CA, Fouladi M, Northcott P, Robinson G, Gajjar A. PMID: 31774708
JCO PRECISION ONCOLOGY – SEPTEMBER 2019
Integrative Molecular Analysis of Patients With Metastatic Cancer
Sailer V, Eng KW, Zhang T, Bareja R, Pisapia DJ, Sigaras A, Bhinder B, Romanel A, Wilkes D, Sticca E, Cyrta J, Rao R, Sahota S, Pauli C, Beg S, Motanagh S, Kossai M, Fontunge J, Puca L, Rennert H, Zhaoying Xiang J, Greco N, Kim R, MacDonald TY, McNary T, Blattner-Johnson M, Schiffman MH, Faltas BM, Greenfield JP, Rickman D, Andreopoulou E, Holcomb K, Vahdat LT, Scherr DS, van Besien K, Barbieri CE, Robinson BD, Fine HA, Ocean AJ, Molina A, Shah MA, Nanus DM, Pan Q, Demichelis F, Tagawa ST, Song W, Mosquera JM, Sboner A, Rubin MA, Elemento O, Beltran H. PMID: 31592503
ONCOLOGY TIMES – NOVEMBER 2019
2019 Excellence in Oncology Award—Dr. Mark Souweidane Honorable Mention. Direct Delivery to Brainstem in Rare Pediatric Tumor Proves Safe.
AUTHOR: Chuck Holt
JOURNAL OF NEUROSURGERY PEDIATRICS – SEPTEMBER 2019
Developing a 3D composite training model for cranial remodeling.
Cheng D, Yuan M, Perera I, O’Connor A, Evins AI, Imahiyerobo T, Souweidane M, Hoffman C.
MOLECULAR PHARMACOLOGY – AUGUST 2019
An [18F]-Positron Emitting Fluorophore Allows Safe Evaluation of Small Molecule Distribution in CSF, CSF Fistulas, and CNS Device Placement.
Guo H, Kommidi H, Maachani UB, Voronina JC, Zhang W, Magge RS, Ivanidze J, Wu AP, Souweidane MM, Aras O, Ting R. PMID: 31290330
ACTA NEUROCHIRURGICA (WIEN) – AUGUST 2019
Endonasal surgery for suprasellar germ cell tumors: two cases and review of the literature.
Arnaout MM, Gerges MM, Cummock MD, El Asri AC, Greenfield JP, Anand VK, Schwartz TH.
OXFORD ACADEMIC NEURO-ONCOLOGY ADVANCES – MAY 2019
Combined Targeting of PI3K and MEK Effector Pathways via CED for DIPG Therapy
Raymond Chang, Umberto Tosi, Julia Voronina, Oluwaseyi Adeuyan, Y Linda Wu, Melanie E Schweitzer, David J Pisapia, Oren J Becher, Mark M Souweidane, Uday B Maachani. Read more about the paper here.
ACS CHEMICAL NEUROSCIENCE – MAY 2019
Real-Time, in Vivo Correlation of Molecular Structure with Drug Distribution in the Brain Striatum Following Convection Enhanced Delivery.
Tosi U, Kommidi H, Bellat V, Marnell CS, Guo H, Adeuyan O, Schweitzer ME, Chen N, Su T, Zhang G, Maachani UB, Pisapia DJ, Law B, Souweidane MM, Ting R.ACS Chem Neurosci. 2019 May 15;10(5):2287-2298. doi: 10.1021/acschemneuro.8b00607. Epub 2019 Mar 6. PMID:30838861
ACTA NEUROPATHOLOGICAL COMMUNICATIONS – APRIL 2019
Transcriptome signatures associated with meningioma progression.
Viaene AN, Zhang B, Martinez-Lage M, Xiang C, Tosi U, Thawani JP, Gungor B, Zhu Y, Roccograndi L, Zhang L, Bailey RL, Storm PB, O’Rourke DM, Resnick AC, Grady MS, Dahmane N. PMID:31039818
NATURE – JANUARY 2019
Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.
Miller AM, Shah RH, Pentsova EI, Pourmaleki M, Briggs S, Distefano N, Zheng Y, Skakodub A, Mehta SA, Campos C, Hsieh WY, Selcuklu SD, Ling L, Meng F, Jing X, Samoila A, Bale TA, Tsui DWY, Grommes C, Viale A, Souweidane MM, Tabar V, Brennan CW, Reiner AS, Rosenblum M, Panageas KS, DeAngelis LM, Young RJ, Berger MF, Mellinghoff IK.
Nature. 2019 Jan;565(7741):654-658. doi: 10.1038/s41586-019-0882-3. Epub 2019 Jan 23. PMID: 30675060
NATURE – JANUARY 2019
JOURNAL OF NEUROSURGERY – DECEMBER 2018
LANCET ONCOLOGY – AUGUST 2018
Convection-enhanced delivery for diffuse intrinsic pontine glioma: a single-centre, dose-escalation, phase 1 trial.
Souweidane MM, Kramer K, Pandit-Taskar N, Zhou Z, Haque S, Zanzonico P, Carrasquillo JA, Lyashchenko SK, Thakur SB, Donzelli M, Turner RS, Lewis JS, Cheung NV, Larson SM, Dunkel IJ.
Lancet Oncol. 2018 Aug;19(8):1040-1050. doi: 10.1016/S1470-2045(18)30322-X. Epub 2018 Jun 18. Erratum in:
Lancet Oncol. 2018 Aug;19(8):e382.
PMID: 29914796
MOLECULAR THERAPY ONCOLYTICS – AUGUST 2018
Checkpoint Blockade Reverses Anergy in IL-13Rα2 Humanized scFv-Based CAR T Cells to Treat Murine and Canine Gliomas.
Yin Y, Boesteanu AC, Binder ZA, Xu C, Reid RA, Rodriguez JL, Cook DR, Thokala R, Blouch K, McGettigan-Croce B, Zhang L, Konradt C, Cogdill AP, Panjwani MK, Jiang S, Migliorini D, Dahmane N, Posey AD Jr, June CH, Mason NJ, Lin Z, O’Rourke DM, Johnson LA. PMID:30306125
JOURNAL OF NEUROSURGERY – JULY 2018
Volume of distribution and clearance of peptide-based nanofiber after convection-enhanced delivery.
Singh R, Bellat V, Wang M, Schweitzer ME, Wu YL, Tung CH, Souweidane MM, Law B.J Neurosurg. 2018 Jul;129(1):10-18. doi: 10.3171/2017.2.JNS162273. Epub 2017 Sep 8. PMID:28885119
NEUROONCOLOGY – JUNE 2018
TBIO-06. B7-H3 expression as a potential biomarker of prognosis and target in pediatric glial and non-glial CNS tumors.
Uday Bhanu Maachani, Zhiping Zhou, Daniel Martinez, Mariarita Santi, Nadia Dahmane, and Mark Souweidane. PMCID: PMC6012773
COLD SPRING HARBOR MOLECULAR CASE STUDIES – APRIL 2018
Precision oncogenomics in pediatrics: a personal reflection.
Campbell C,
Greenfield JP.
Cold Spring Harb Mol Case Stud. 2018 Apr 2;4(2). pii: a002865. doi: 10.1101/mcs.a002865. Print 2018 Apr. Review.
PMID: 29610396. Free PMC Article
JOURNAL OF NUCLEAR MEDICINE – MARCH 2018
PARP-1-Targeted Radiotherapy in Mouse Models of Glioblastoma.
Jannetti SA, Carlucci G, Carney B, Kossatz S, Shenker L, Carter LM, Salinas B, Brand C, Sadique A, Donabedian PL, Cunanan KM, Gönen M, Ponomarev V, Zeglis BM, Souweidane MM, Lewis JS, Weber WA, Humm JL, Reiner T.
JOURNAL OF NEUROONCOLOGY – MARCH 2018
Patterns of relapse for children with localized intracranial ependymoma.
De B, Khakoo Y, Souweidane MM, Dunkel IJ, Patel SH, Gilheeney SW, De Braganca KC, Karajannis MA, Wolden SL.J
PEDIATRIC BLOOD CANCER – JANUARY 2018
A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma.
Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV.Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26754. Epub 2017 Sep 22. PMID:28940863
PEDIATRIC BLOOD CANCER – SEPTEMBER 2017
A phase II study of radioimmunotherapy with intraventricular 131 I-3F8 for medulloblastoma.
Kramer K, Pandit-Taskar N, Humm JL, Zanzonico PB, Haque S, Dunkel IJ, Wolden SL, Donzelli M, Goldman DA, Lewis JS, Lyashchenko SK, Khakoo Y, Carrasquillo JA, Souweidane MM, Greenfield JP, Lyden D, De Braganca KD, Gilheeney SW, Larson SM, Cheung NV.Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26754. Epub 2017 Sep 22. PMID: 28940863
PALLIATIVE SUPPORT CARE – SEPTEMBER 2017
Rapid autopsy of a patient with recurrent anaplastic ependymoma.
Lange KR, Fischer C,
Rajappa P, Connors S, Pisapia D,
Greenfield JP, Beltran H, Rubin M, Mosquera JM, Khakoo Y.
Palliat Support Care. 2018 Apr;16(2):238-242. doi: 10.1017/S1478951517000864. Epub 2017 Sep 25.
PMID: 28942746 Free PMC ArticleJCO PRECISION ONCOLOGY – JUNE 2017
Next-Generation Rapid Autopsies Enable Tumor Evolution Tracking and Generation of Preclinical Models.
Pisapia DJ, Salvatore S, Pauli C, Hissong E, Eng K, Prandi D, Sailer VW, Robinson BD, Park K, Cyrta J, Tagawa ST, Kossai M, Fontugne J, Kim R, Sigaras A, Rao R, Pancirer D, Faltas B, Bareja R, Molina AM, Nanus DM,
Rajappa P,
Souweidane MM,
Greenfield J, Emde AK, Robine N, Elemento O, Sboner A, Demichelis F, Beltran H, Rubin MA, Mosquera JM.
JCO Precis Oncol. 2017;2017. doi: 10.1200/PO.16.00038. Epub 2017 Jun 14.
PMID: 29333526 . Free PMC Article
CLINICAL CANCER RESEARCH – JUNE 2017
Malignant Astrocytic Tumor Progression Potentiated by JAK-mediated Recruitment of Myeloid Cells.
Rajappa P, Cobb WS, Vartanian E, Huang Y, Daly L, Hoffman C, Zhang J, Shen B, Yanowitch R, Garg K, Cisse B, Haddock S, Huse J, Pisapia DJ, Chan TA, Lyden DC, Bromberg JF, Greenfield JP. PMID:28039266
JOURNAL OF CLINICAL INVESTIGATION – MAY 2017
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma.
Huang Y, Rajappa P, Hu W, Hoffman C, Cisse B, Kim JH, Gorge E, Yanowitch R, Cope W, Vartanian E, Xu R, Zhang T, Pisapia D, Xiang J, Huse J, Matei I, Peinado H, Bromberg J, Holland E, Ding BS, Rafii S, Lyden D, Greenfield J. PMID:28394259
CANCER RESEARCH – APRIL 2017
Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.
Kossatz S, Carney B, Schweitzer M, Carlucci G, Miloushev VZ, Maachani UB, Rajappa P, Keshari KR, Pisapia D, Weber WA, Souweidane MM, Reiner T.
